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Research

What Is Molecular Hydrogen (H2) and How Does It Work in My Body?

The Danger of Free Radicals

Free radicals are rogue molecules that have the ability to harass and even destroy other molecules in your cells by stealing electrons from innocent molecules, and cause instability in these molecules, then they become free radical themselves, disrupting other molecules in the vicinity. In this way, free radical can start a chain reaction in the body’s tissues, causing damage that can destroy the structure and function of cells in your tissues. This revolution of unmanaged free radicals in your tissues is known as oxidative stress.

Research has shown that if you allow these free radicals to get out of hand and cause oxidative stress, they will stimulate nociceptors and cause aches and pain. The presence of oxidative stress in myofascial tissues can easily generate an inflammatory response in muscles and joints. In chronic muscle and joint disorders, the presence of chronic inflammation and oxidative stress in your tissues is inseparable. Therefore, to correctly deal with chronic muscle and joint problems, it is a requirement to learn how to manage the metabolic factor of chronic inflammation and oxidative stress.

By Greg Fors, in his book title, Why We Hurt: A Complete Physical & Spiritual Guide to Healing Your Chronic Pain.

Molecular Hydrogen a Potential “Novel” Antioxidant

Molecular Hydrogen has been scientifically proven to have antioxidant properties that help to remove free radicals from your body that cause premature aging. Dr. Shigeo Ohta and his team of researchers have proposed that molecular hydrogen has potential as “novel” antioxidant without adverse effect. Hydrogen has a number of advantages as a potential antioxidant: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effect of consuming H2. Moreover, H2 shows not only effects against oxidative stress, but also various anti-inflammatory effects. H2 passes through the blood brain barrier, although most antioxidant compounds cannot.

How are plant based antioxidants found in foods similar to Molecular Hydrogen?

  • They are both natural to the body.
  • They are both neither artificial nor synthetic.
  • They are both promoting wellness.

How is Molecular Hydrogen different to antioxidants in foods?

  • Molecular Hydrogen only scavenges the bad free radical.
  • Molecular Hydrogen leaves no waste product after neutralizing a free radical.
  • Molecular Hydrogen also increases our body’s own antioxidant systems.
  • Molecular Hydrogen also acts as a signalling molecule, thus having many other benefits.
  • Molecular Hydrogen is the smallest molecule, which can easily enter the cells. ( Note: H2 only weight 2g/mole vs vitamin C at 176.2 g/mole)
  • Molecular Hydrogen has no known toxic effects at high intakes.

Which gets rid of more free radicals: Vitamin C or Molecular Hydrogen?

Based on stoichiometry, one molecule of vitamin C can theoretically neutralize two free radicals, which is the same for Molecular Hydrogen. However, some of the used vitamin C molecules can be rejuvenated by the bodies and be used again, which is not the case with Molecular Hydrogen. On the other hand, Molecular Hydrogen can upregulate powerful antioxidant enzymes in the body, thus providing further protection, a function which vitamin C cannot do. Interestingly, vitamin C intake at high levels may actually prevent this upregulation from occurring.

Interview with Professor Shigeo Ohta, Nippon Medical School, Japan; Pioneer Researcher in the Field of Hydrogen as a Therapeutic Antioxidant by selectively reducing Cytotoxic Oxygen Radicals​

A discussion about therapeutic hydrogen gas between Tyler W. LeBaron, Executive Director of the Molecular Hydrogen Institute (MHI), and pioneer hydrogen researcher, Dr. Shigeo Ohta

COVID-19 Pathophysiology & the Rationale for why Molecular Hydrogen is being clinically investigated

Update on information relating to the benefits of hydrogen for the coronavirus.

Nobel Prize Nominee, Dr. GARTH NICOLSON on the Safety & Health Benefits of Hydrogen

劉燦榮教授談氫與自由基

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine ~ Garth L. Nicolson and Shigeo Ohta. International Journal of Clinical Medicine (2016).

Hydrogen acts as a Therapeutic Antioxidant by selectively reducing cytotoxic oxygen radicals ~ S.Ohta et al, Nippon Medical School, Japan. Nature Medicine  (2007).

Recent advances in Hydrogen research as a therapeutic medical gas ~ T. Kawamura et al. Free Radical Research (2010).

Molecular Hydrogen: New antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases ~ T. Ishibashi, Haradoi Hospital, Japan. Current Pharmaceutical Design (2013).

Hydrogen: another gas with Therapeutic Potential ~ James F. George and Anupam Agarwal. Kidney International (2010).

Molecular Hydrogen as an Emerging Candidate for Preventing Alzheimer's Disease ~ Shigeo Ohta and Takashi Asada. Int. J Alzheimers & Neuro Disorder 2018

Molecular Hydrogen improves Obesity and Diabetes by inducing hepatic FGF21 and stimulating energy metabolism in mice ~ Kamimura N1, Nishimaki K, Ohsawa I, Ohta S. NCBI US National Library of Medicine National Institutes of Health

Recent Advances in Hydrogen Research as a Therapeutic Medical Gas ~ Chien Sheng Huang, Tomohiro Kawamura, Yoshiya Toyoda, Atsunori Nakao. Free Radical Research (2010).

Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications ~ Shigeo Ohta. Current Pharmaceutical Design (2011).

Therapeutic efficacy of infused Molecular Hydrogen in saline on Rheumatoid Arthritis ~ Toru Ishibashi. International Immunopharmacology Journal (2014)

Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats ~ Song Xue Guo, Yun Yun Jin, Quan Fang, Chuan Gang You, Xin Gang Wang, Xin Lei Hu, Chun-Mao Han. PLOS ONE (2015).

Can Hydrogen retard the progression of Osteoarthritis ~ Ding Li and WanChun Wang. African Journal of Pharmacy and Pharmacology Vol. 6(5), 2012.

Molecular Hydrogen: An overview of its Neurobiological effects and Therapeutic potential for Bipolar disorder and Schizophrenia ~ Ahmad Ghanizadeh and Micheal Berk. Medical Gas Research (2013).

Hydrogen Gas in Cancer Treatment ~ Sai Li, Rongrong Liao, Xiaoyan Sheng, Xiaojun Luo, Xin Zhang, Xiaomin Wen, Jin Zhou and Kang Peng frontiers in Oncology

Hydrogen – Therapeutic Potential in Wellness and Medicine ~ M. Lemaire & F. BarbierJournal of Aging Research & Clinical Practice

Insufflation of Hydrogen Gas Restrains the Inflammatory Response of Cardiopulmonary Bypass in a Rat Model ~ Eisuke Tatsumi, Hirotsugu Tsuchimochi James Pearson.Artificial Organs (2013)

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury ~ Kentaro Hayashida, Shigeo Ohta + 10 More.Biochemical and Biophysical Research Communications, 2008

Hydrogen therapy: from mechanism to cerebral diseases ~ Cheng-lin Liu#, Kai Zhang#, Gang Chen. Medical Gas Res (2016)

H2 mediates Cardioprotection via Involvements of KATP Channels and Permeability transition pores of Mitochondria in Dogs ~ Akemi Yoshida, Hiroshi Asanuma + 14 more.Cadiovasc Drugs Ther (2012)

Hydrogen Medicine Therapy: An Effective and Promising Novel Treatment for Multiple Organ Dysfunction Syndrome (MODS) Induced by Influenza and Other Viral Infections Diseases ~ Ming Yang, Zheng Zhang, Bo Gao. SOJ Microbiol Infect Dis 5(2): 1-6.

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia, the 7th Trial Edition ~ National Health Commission of the People's Republic of China, 2020-03-05 [WHO Translation]

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study ~ Toshio Mikami, Kohei Tano, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, Tyler W. LeBaron, Shigeo Ohta. Canadian Journal of Physiology and Pharmacology

Hydrogen therapy for Covid-19 acute respiratory distress syndrome (ARDS) ~ Medium

A novel functional beverage for COVID-19 and other conditions: Hypothesis and preliminary data, increased blood flow, and wound healing ~ LeBaron TW, McCullough ML and Ruppman Sr KH. Journal of Translational Science

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